کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2103801 1546314 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Can G-CSF Cause Leukemia in Hematopoietic Stem Cell Donors?
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Can G-CSF Cause Leukemia in Hematopoietic Stem Cell Donors?
چکیده انگلیسی

A large majority of allogeneic hematopoietic stem cell donations are achieved using granulocyte-colony stimulating factor (G-CSF). G-CSF use has been associated with later development of myelodysplastic syndromes/acute myelogenous leukemia (MDS/AML) in several clinical circumstances. Although clinical data to date have failed to identify any increased incidence of MDS/AML in G-CSF mobilized donors, the quality of these data are insufficient to exclude a long-term risk. Physicians should explain the potential risk to donors, and where appropriate, offer donors the option of marrow donation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 17, Issue 12, December 2011, Pages 1739–1746
نویسندگان
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