کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2106709 | 1083620 | 2016 | 16 صفحه PDF | دانلود رایگان |
• Lung tumors accumulate a subset of TANs with a granulocyte and APC hybrid phenotype
• APC-like hybrid neutrophils are able to stimulate the anti-tumor T cell responses
• IFN-γ and GM-CSF are requisite factors for the development of hybrid neutrophils
• Ikaros negatively regulates the development of hybrid neutrophils from progenitors
SummaryBased on studies in mouse tumor models, granulocytes appear to play a tumor-promoting role. However, there are limited data about the phenotype and function of tumor-associated neutrophils (TANs) in humans. Here, we identify a subset of TANs that exhibited characteristics of both neutrophils and antigen-presenting cells (APCs) in early-stage human lung cancer. These APC-like “hybrid neutrophils,” which originate from CD11b+CD15hiCD10−CD16low immature progenitors, are able to cross-present antigens, as well as trigger and augment anti-tumor T cell responses. Interferon-γ and granulocyte-macrophage colony-stimulating factor are requisite factors in the tumor that, working through the Ikaros transcription factor, synergistically exert their APC-promoting effects on the progenitors. Overall, these data demonstrate the existence of a specialized TAN subset with anti-tumor capabilities in human cancer.
Journal: - Volume 30, Issue 1, 11 July 2016, Pages 120–135