کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2109804 1083890 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
ترجمه فارسی عنوان
der (11) t (4؛ 11) (q21؛ p15) در بیمار T-ALL/LBL
کلمات کلیدی
لوسمی حاد/لنفوم حاد سلولی T؛ سیتوژنتیک؛ FISH؛ کاريوتيپ طيفي
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی

Translocation t(4;11)(q21;p15) is a rare recurrent change associated to T-cell acute leukemia. In most cases, this alteration appears as the only abnormality or as part of a simple karyotype. In this report, we present the first case of T acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) with the unbalanced translocation der(11)t(4;11)(q21;p15) as part of a very complex karyotype with multiple chromosome abnormalities, most of them not previously described in the literature. FISH (fluorescence in situ hybridization) and spectral karyotype (HiSKY) analysis confirmed the presence of complex alterations. The patient, a 16-year-old male, showed poor response to treatment and short survival (11 months). A detailed review of previously reported cases with t(4;11)(q21;p15) is also provided. The description of this type of alterations may contribute to the identification of new molecular mechanism associated to neoplastic development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Genetics - Volume 209, Issue 4, April 2016, Pages 166–170
نویسندگان
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