کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2112539 1084395 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Non-targeted effects induced by ionizing radiation: Mechanisms and potential impact on radiation induced health effects
ترجمه فارسی عنوان
اثرات غیر هدفمند ناشی از اشعه یونیزاسیون: مکانیسم ها و تاثیر بالقوه بر اثرات سلامت ناشی از تابش
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


• Cell-to-cell communication between irradiated cells and non-irradiated cells (NTE's) and its potential impact on human health.
• Speculation on the factors that might be involved in communicating responses from irradiated cells to non-irradiated cells and eliciting an effect.
• Relationships between irradiated cells and non-irradiated cells and the implications for delayed health effects.

Not-targeted effects represent a paradigm shift from the “DNA centric” view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (>1 Gy), at low doses (<100 mGy) non-targeted effects associated with radiation exposure might play a significant role. Here definitions of non-targeted effects are presented, the potential mechanisms for the communication of signals and signaling networks from irradiated cells/tissues are proposed, and the various effects of this intra- and intercellular signaling are described. We conclude with speculation on how these observations might lead to and impact long-term human health outcomes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 356, Issue 1, 1 January 2015, Pages 17–21
نویسندگان
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