کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2112539 | 1084395 | 2015 | 5 صفحه PDF | دانلود رایگان |
• Cell-to-cell communication between irradiated cells and non-irradiated cells (NTE's) and its potential impact on human health.
• Speculation on the factors that might be involved in communicating responses from irradiated cells to non-irradiated cells and eliciting an effect.
• Relationships between irradiated cells and non-irradiated cells and the implications for delayed health effects.
Not-targeted effects represent a paradigm shift from the “DNA centric” view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (>1 Gy), at low doses (<100 mGy) non-targeted effects associated with radiation exposure might play a significant role. Here definitions of non-targeted effects are presented, the potential mechanisms for the communication of signals and signaling networks from irradiated cells/tissues are proposed, and the various effects of this intra- and intercellular signaling are described. We conclude with speculation on how these observations might lead to and impact long-term human health outcomes.
Journal: Cancer Letters - Volume 356, Issue 1, 1 January 2015, Pages 17–21