کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2112545 1084395 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects
چکیده انگلیسی


• Non-targeted effects in response to radiation are well established in cell culture models and are now beginning to be understood in vivo.
• The mechanism for non-targeted effects have been shown to involve direct cell to cell communication, secreted factors and immune responses.
• Oxidative DNA damage has been shown to be a common endpoint for both irradiated tissue and inflammatory responses such as that induced by tumours.
• Cytokines and reactive species are key molecules involved in these non-targeted effects.

A spectrum of radiation-induced non-targeted effects has been reported during the last two decades since Nagasawa and Little first described a phenomenon in cultured cells that was later called the “bystander effect”. These non-targeted effects include radiotherapy-related abscopal effects, where changes in organs or tissues occur distant from the irradiated region. The spectrum of non-targeted effects continue to broaden over time and now embrace many types of exogenous and endogenous stressors that induce a systemic genotoxic response including a widely studied tumor microenvironment. Here we discuss processes and factors leading to DNA damage induction in non-targeted cells and tissues and highlight similarities in the regulation of systemic effects caused by different stressors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 356, Issue 1, 1 January 2015, Pages 72–81
نویسندگان
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