کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2112993 | 1084432 | 2013 | 8 صفحه PDF | دانلود رایگان |
The present study provides novel insight into the mechanism of apoptosis induction by withaferin A (WA), which is a bioactive constituent of an Ayurvedic medicine plant (Withania somnifera). Exposure of MDA-MB-231 and MCF-7 human breast cancer cells to WA resulted in suppression of XIAP, cIAP-2, and Survivin protein levels. The WA-induced apoptosis was significantly attenuated by ectopic expression of XIAP, Survivin, and cIAP-2 in both cells. However, the WA-mediated inhibition of MDA-MB-231 xenograft growth in vivo was associated with suppression of Survivin protein level only. These results indicate important contribution of Survivin suppression in WA-induced apoptosis.
► Withaferin A downregulates IAP family proteins in breast cancer cells.
► Overexpression of XIAP, cIAP-2 and Survivin confers protection against withaferin A-induced apoptosis.
► Withaferin A administration suppresses Survivin protein level in vivo..
► Survivin may be a valid biomarker of withaferin A exposure and possibly response at least in breast cancer cells.
Journal: Cancer Letters - Volume 334, Issue 1, 28 June 2013, Pages 101–108