کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2116888 | 1085040 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Continuous administration of the three thrombospondin-1 type 1 repeats recombinant protein improves the potency of therapy in an orthotopic human pancreatic cancer model
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کلمات کلیدی
SCIDMVDHDMECContinuous administrationBSA - BSAbovine serum albumin - آلبومین سرم گاوAngiogenesis - آنژیوژنزMicrovessel density - تراکم MicrovesselThrombospondin-1 - ترومبوسپوندن-1Anti-angiogenic therapy - درمان آنتی ژنیکPancreatic cancer - سرطان پانکراسVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Vascular endothelial cell growth factor - فاکتور رشد سلول اندوتلیال عروقیOrthotopic model - مدل Orthotopialsevere combined immunodeficient - کمبود ایمنی ترکیبی شدید
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Thrombospondin-1 is one of most important natural angiogenic inhibitors. The three thrombospondin-1 type 1 repeats (3TSR), an anti-angiogenic domain of thrombospondin-1, is a promising novel agent for anti-angiogenic treatment. In the present study, we showed 3TSR was biologically stable at least for 7 days in mini-osmotic pumps in vivo, and continuous administration of 3TSR decreased the dosage and improved the potency of therapy in an orthotopic pancreatic cancer model. By using different dosage and delivery routes, we proved that the anti-tumor efficacy of 3TSR was correlated with its anti-angiogenic efficacy. 3TSR treatment also decreased tumor vessel patency and blood flow. The results indicate the advantage of continuous administration of angiogenic inhibitors and provide rationale for using such delivery methods for cancer treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 247, Issue 1, 8 March 2007, Pages 143-149
Journal: Cancer Letters - Volume 247, Issue 1, 8 March 2007, Pages 143-149
نویسندگان
Xuefeng Zhang, Caitlin Connolly, Mark Duquette, Jack Lawler, Sareh Parangi,