کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2130198 1086536 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Translational potential of cancer stem cells: A review of the detection of cancer stem cells and their roles in cancer recurrence and cancer treatment
ترجمه فارسی عنوان
پتانسیل ترجمه سلول های بنیادی سرطانی: بررسی تشخیص سلول های بنیادی سرطانی و نقش آنها در عود سرطان و درمان سرطان
کلمات کلیدی
سلول بنیادی سرطانی، رفتار، متاستازها، مقاوم در برابر درمان، درمان هدفمند
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
چکیده انگلیسی


• Cancer stem cells play an important role in cancer metastases.
• Cancer stem cells contribute to treatment resistance and recurrence in cancer.
• Understanding the biology, isolation and targeting of cancer stem cell are important in future management of cancer.

Cancer stem cells (CSCs) are a subpopulation of cancer cells with many clinical implications in most cancer types. One important clinical implication of CSCs is their role in cancer metastases, as reflected by their ability to initiate and drive micro and macro-metastases. The other important contributing factor for CSCs in cancer management is their function in causing treatment resistance and recurrence in cancer via their activation of different signalling pathways such as Notch, Wnt/β-catenin, TGF-β, Hedgehog, PI3K/Akt/mTOR and JAK/STAT pathways. Thus, many different therapeutic approaches are being tested for prevention and treatment of cancer recurrence. These may include treatment strategies targeting altered genetic signalling pathways by blocking specific cell surface molecules, altering the cancer microenvironments that nurture cancer stem cells, inducing differentiation of CSCs, immunotherapy based on CSCs associated antigens, exploiting metabolites to kill CSCs, and designing small interfering RNA/DNA molecules that especially target CSCs. Because of the huge potential of these approaches to improve cancer management, it is important to identify and isolate cancer stem cells for precise study and application of prior the research on their role in cancer. Commonly used methodologies for detection and isolation of CSCs include functional, image-based, molecular, cytological sorting and filtration approaches, the use of different surface markers and xenotransplantation. Overall, given their significance in cancer biology, refining the isolation and targeting of CSCs will play an important role in future management of cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 335, Issue 1, 1 July 2015, Pages 135–147
نویسندگان
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