کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2144680 | 1548006 | 2016 | 15 صفحه PDF | دانلود رایگان |
• Osteoclasts resorb bone and have a “love–hate” relationship with the bone matrix.
• They are tightly regulated by the bone matrix components.
• Their activity contributes to the body homeostasis.
Osteoclasts are unique cells that destroy the mineralized matrix of the skeleton. There is a “love–hate” relationship between the osteoclasts and the bone matrix, whereby the osteoclast is stimulated by the contact with the matrix but, at the same time, it disrupts the matrix, which, in turn, counteracts this disruption by some of its components. The balance between these concerted events brings about bone resorption to be controlled and to contribute to bone tissue integrity and skeletal health. The matrix components released by osteoclasts are also involved in the local regulation of other bone cells and in the systemic control of organismal homeostasis. Disruption of this regulatory loop causes bone diseases, which may end up with either reduced or increased bone mass, often associated with poor bone quality. Expanding the knowledge on osteoclast-to-matrix interaction could help to counteract these diseases and improve the human bone health. In this article, we will present evidence of the physical, molecular and regulatory relationships between the osteoclasts and the mineralized matrix, discussing the underlying mechanisms as well as their pathologic alterations and potential targeting.
Journal: Matrix Biology - Volumes 52–54, May–July 2016, Pages 176–190