کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167054 1092303 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Low level of LAT-PLC-γ1 interaction is associated with Th2 polarized differentiation: A contributing factor to the etiology of asthma
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Low level of LAT-PLC-γ1 interaction is associated with Th2 polarized differentiation: A contributing factor to the etiology of asthma
چکیده انگلیسی
Linker for activation of T cells (LAT) is a key adaptor in the T cell receptor (TCR) signaling pathway. The expression of LAT is lower in asthmatic patients than that in healthy people, but there is little knowledge about the mechanism underlying this phenomenon. This study was aimed to determine whether LAT-PLC-γ1 interaction was involved in the development of asthma. It was shown that the phosphorylation of PLC-γ1 decreased in the asthmatic mouse model and Th2 cell differentiated CD4+ T cells. In addition, depleted endogenous PLC-γ1 promoted CD4+ T cells to differentiate into IL-4-Productor. It was therefore concluded that the low level of LAT-PLC-γ1 interaction was associated with Th2 polarized differentiation, and this may contribute to the etiology of asthma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 290, Issue 1, July 2014, Pages 131-137
نویسندگان
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