کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167275 1092323 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Extracellular acidosis promotes neutrophil transdifferentiation to MHC class II-expressing cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Extracellular acidosis promotes neutrophil transdifferentiation to MHC class II-expressing cells
چکیده انگلیسی

Inflammation in peripheral tissues is usually associated with local acidosis. In the present study, we demonstrate that extracellular acidification enhances GM-CSF- and IFN-γ-induced expression of HLA-DR, CD80 and CD86 in human neutrophils (neutrophil transdifferentiation), and potentiates antigen-capturing capacities (both endocytosis and phagocytosis) of the transdifferentiated cells. Furthermore, in acidic conditions the transdifferentiated neutrophils have stronger antigen-presenting capacity, inducing more intense proliferation of autologous T lymphocytes in the presence of staphylococcal enterotoxin A. Thus, extracellular acidosis can represent a factor that promotes neutrophil transdifferentiation and potentiates the functional abilities of the transdifferentiated cells in inflammatory foci in vivo.


► Acidosis enhances cytokine-induced expression of MHC class II in neutrophils.
► Acidosis potentiates antigen uptake by MHC class II-expressing neutrophils.
► Acidosis potentiates antigen presentation by MHC class II-expressing neutrophils.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 271, Issue 2, 2011, Pages 214–218
نویسندگان
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