کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167282 1092323 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synergy between TLR3 and IL-18 promotes IFN-γ dependent TRAIL expression in human liver NK cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Synergy between TLR3 and IL-18 promotes IFN-γ dependent TRAIL expression in human liver NK cells
چکیده انگلیسی

Natural killer (NK) cells are a component of innate immunity against viral infections through their rapid cytotoxic activity and cytokine production. However, intra-hepatic NK cells’ ability to respond to virus is still mostly unknown. Our results show that the synthetic dsRNA polyinosinic–polycytidylic acid (poly I:C), a mimic of a common product of viral infections, activates NK cells directly in the context of cytokines found in the liver, i.e.: poly I:C plus inflammatory cytokines (IL-18, IL-12, and IL-2) induced NK cell IFN-γ production and TRAIL expression, and anti-inflammatory cytokines (TGF-β and IL-10) inhibit NK cell IFN-γ production. Neutralization of IFN-γ blocks poly I:C plus inflammatory cytokines-induced NK cell TRAIL expression, suggesting that IFN-γ is an autocrine differentiation factor for these cells. A better understanding of the intra-hepatic NK cell activation against viral infection may help in the design of therapies and vaccines for the control of viral hepatitis.


► Poly I:C plus inflammatory cytokines activate NK cell.
► Anti-inflammatory cytokines inhibit NK cell.
► IFN-γ acts as autocrine.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 271, Issue 2, 2011, Pages 286–291
نویسندگان
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