کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2167368 | 1549411 | 2012 | 5 صفحه PDF | دانلود رایگان |
We compared the purities, phenotype, capabilities of antigen uptake and T lymphocytes stimulation abilities of adherent and non-adherent cells of human monocyte-derived dendritic cells (mono-DCs) in GM-CSF, IL-4 and TNF-α culture system. The results show that both the purities and the capabilities of antigen uptake of the adherent DCs are significantly higher than those of non-adherent ones. As for the expression levels of surface markers and the abilities of stimulating lymphocytes proliferation, our results also show that those of adherent DCs are a bit higher than those of non-adherent ones, although the differences are not significant.
► Adherent cells are purer dendritic cells than non-adherent cells.
► Adherent cells are superior in antigen uptake capability.
► Expression level of surface marker of adherent dendritic cells is a bit higher.
► Adherent cells stimulate lymphocyte proliferation more effectively.
Journal: Cellular Immunology - Volume 277, Issues 1–2, May–June 2012, Pages 44–48