کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167370 1549411 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microarray analysis of the gene expression profile of HMC-1 mast cells following Schizonepeta tenuifolia Briquet treatment
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Microarray analysis of the gene expression profile of HMC-1 mast cells following Schizonepeta tenuifolia Briquet treatment
چکیده انگلیسی

It has long been believed that mast cells play a crucial role in the development of many physiological changes during immediate allergic responses. This study was conducted to evaluate the anti-inflammation mechanism of Schizonepeta tenuifolia (ST) extract and ST purified chemicals on the PMA plus A23187-induced stimulation of HMC-1 human mast cells. ST, rosmarinic acid, pulegone, and 2α,3α,24-thrihydrooxylen-12en-28oic acid treatment of HMC-1 cells led to significant suppression of pro-inflammatory cytokines (IL-6, IL-8, and TNF-α) in a dose dependent manner. In addition, the results of the microarray and real-time RT-PCR analyses revealed that ST regulates several pathways, including the cytokine-cytokine receptor interaction (CCRI), MAPK, and the Toll-like receptor (TLR) signaling pathways. ST may be useful for the treatment of inflammation disease via anti-inflammation activity that occurs through inhibition of the CCRI, MAPK, and TLR signaling pathways.


► Schizonepeta tenuifolia (ST) extract and ST purified chemicals have anti-inflammation activity.
► ST purified chemicals were found to inhibit the secretion of TNF-α, IL-6, and IL-8 by human mast cells.
► ST and rosmarinic acid exerted similar effects against inflammation.
► ST may have anti-inflammation activity that occurs via inhibition of the Toll-like and MAPK signaling pathways.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 277, Issues 1–2, May–June 2012, Pages 58–65
نویسندگان
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