کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2167388 | 1092327 | 2012 | 11 صفحه PDF | دانلود رایگان |
FCRLA is an intracellular B cell protein that belongs to the FcR-like family. Using newly generated FCRLA-specific antibodies, we studied the constitutive expression pattern of mouse FCRLA and monitored changes during an immune response and following in vitro B cell activation. All B cell subpopulations examined expressed FCRLA. However, the level of FCRLA expression is determined by the stage of B cell differentiation. Low expression of FCRLA is characteristic of naïve follicular and marginal zone B cells. High expression was detected in a small fraction of activated B cells scattered along migratory pathways in the lymphoid tissues. FCRLA-bright cells could be subdivided into two subpopulations, with high and low/undetectable level of intracellular immunoglobulins, which phenotypically resemble either plasma or memory B cells. High expression of FCRLA in subset(s) of terminally differentiated B-cells suggests that, being an ER protein, FCRLA may participate in the regulation of immunoglobulin assembly and secretion.
► We characterize FCRLA expression pattern in mouse.
► We show that FCRLA is differentially expressed during mouse B cell differentiation.
► Weak FCRLA expression is characteristic of naïve follicular and MZ B cells.
► FCRLA expression is upregulated in small subset(s) of activated B cells.
Journal: Cellular Immunology - Volume 272, Issue 2, 2012, Pages 182–192