کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2170040 | 1093246 | 2009 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Translational control from head to tail
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
mRNA translation, a highly coordinated affair involving many proteins and RNAs, is generally divided into three steps: initiation, elongation, and termination. Each of these steps serves as a point of regulation to control the amount of protein that is produced. The protein 4E-HP has recently been shown to disrupt recruitment of the translation initiation complex by directly binding the 5â² cap of cellular mRNAs. Recent work has shown elongation rates are probably altered during mitosis and certain types of synaptic transmission. Other work has shown premature termination of mRNAs lacking stop codons appears to repress their translation. Together, these studies highlight the importance of translational control in diverse processes such as development, cancer, and synaptic plasticity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Cell Biology - Volume 21, Issue 3, June 2009, Pages 444-451
Journal: Current Opinion in Cell Biology - Volume 21, Issue 3, June 2009, Pages 444-451
نویسندگان
Rachel Groppo, Joel D Richter,