کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2170427 | 1549496 | 2016 | 15 صفحه PDF | دانلود رایگان |
• SLPI plays a critical role in regulating host defense responses through multiple mechanisms.
• SLPI restrains excessive responses to microbiota at epithelial body barriers.
• SLPI controls microbial infection through its effects on microbes and the host.
• SLPI exhibits anti-inflammatory properties in allergy and autoimmunity.
• SLPI controls key steps of wound healing.
• SLPI regulates cell renewal, differentiation and apoptosis.
Secretory leukocyte protease inhibitor (SLPI), a ∼12 kDa nonglycosylated cationic protein, is emerging as an important regulator of innate and adaptive immunity and as a component of tissue regenerative programs. First described as an inhibitor of serine proteases such as neutrophil elastase, this protein is increasingly recognized as a molecule that benefits the host via its anti-proteolytic, anti-microbial and immunomodulatory activities. Here, we discuss the diverse functions of SLPI. Moreover, we review several novel layers of SLPI-mediated control that protect the host from excessive/dysregulated inflammation typical of infectious, allergic and autoinflammatory diseases and that support healing responses through affecting cell proliferation, differentiation and apoptosis.
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Journal: Cytokine & Growth Factor Reviews - Volume 28, April 2016, Pages 79–93