Novel glucose sensor with Au@Ag heterogeneous nanorods based on electrocatalytic reduction of hydrogen peroxide at negative potential

• Au@Ag heterogeneous NRs showed favorable electrocatalytic ability to reduce H2O2 at negative potential.
• Glucose sensor based on GOx/Au@Ag heterogeneous NRs modified electrode working at neutral pH buffer.
• The sensor exhibited wide linear range of 0.02–10 mM glucose.
• This sensor showed selectivity to possible interferents including 0.15 M Cl−.

A novel electrochemical glucose sensor based on Au@Ag heterogeneous nanorods (Au@Ag heterogeneous NRs) was developed. The Au@Ag heterogeneous NRs exhibited favorable electrocatalytic ability to reduce H2O2 at negative potential of about −0.6 V (vs. SCE). Further, the glucose oxidase (GOx)/Au@Ag heterogeneous NRs modified electrode was constructed as a glucose sensor, which exhibited wide linear range of 0.02–10 mM glucose in O2-saturated phosphate buffered saline (PBS) at an applied potential of −0.4 V. Additionally, the glucose sensor showed good reproducibility and stability. Further, the proposed sensor showed good selectivity to common interferents (ascorbic acid, uric acid and dopamine), other saccharides, and 0.15 M chloride ions, which could be applicable for real human serum sample analysis.