New electrode architectures based on poly(methylene green) and functionalized carbon nanotubes: Characterization and application to detection of acetaminophen and pyridoxine

• New sensors based on poly(methylene green) (PMG) and carbon nanotubes (fCNT).
• Synergistic effect between PMG and fCNT lead to superior electrode platforms.
• PMG/fCNT and fCNT/PMG modified electrodes as acetaminophen and pyridoxine sensors.
• Acetaminophen and pyridoxine determined in pharmaceutical samples.

New electrode platforms have been constructed containing the redox polymer poly(methylene green) (PMG) and functionalized carbon nanotubes (fCNT) in two configurations, the first containing MG electropolymerised on a graphite composite electrode (CE) and covered with fCNT (fCNT/PMG/CE), the second having the MG electropolymerised on top of fCNT modified CE (PMG/fCNT/CE). Modified electrodes with both configurations were characterized by cyclic voltammetry and electrochemical impedance spectroscopy, and compared with PMG/CE and fCNT/CE and CE, in order to evaluate the role of each component in the modified electrode architecture. The modified electrodes were applied to the detection of acetaminophen and pyridoxine, by fixed potential amperometry and differential pulse voltammetry, the latter allowing the simultaneous detection of both analytes. The analytical properties of fCNT/PMG/CE and PMG/fCNT/CE sensors were obtained and the best analytical performance compared with recently reported acetaminophen and pyridoxine sensors. Determination of both analytes in pharmaceutical samples was successfully performed.

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