کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2189657 | 1096218 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antibody Elbow Angles are Influenced by their Light Chain Class
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
We have examined the elbow angles for 365 different Fab fragments, and observe that Fabs with λ light chains have adopted a wider range of elbow angles than their κ chain counterparts, and that the λ light chain Fabs are frequently found with very large (>195°) elbow angles. This apparent hyperflexibility of λ chain Fabs may be due to an insertion in their switch region, which is one residue longer than in κ chains, with glycine occurring most frequently at the insertion position. A new, web-based computer program that was used to calculate the Fab elbow angles is described.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Biology - Volume 357, Issue 5, 14 April 2006, Pages 1566–1574
Journal: Journal of Molecular Biology - Volume 357, Issue 5, 14 April 2006, Pages 1566–1574
نویسندگان
Robyn L. Stanfield, Adam Zemla, Ian A. Wilson, Bernhard Rupp,