Albumin adsorption influence on the stability of the mesoporous zirconia suspension

In this paper, the stability mechanism of the mesoporous zirconia suspension in the albumin presence was described. The albumin adsorption on the zirconia surface depends on pH and ionic strength. The highest adsorption was observed at the albumin pI value (for HSA 3.1 mg/m2). The protein adsorption affects the suspension stability. It causes mainly its increase related to electrosteric stabilization phenomenon (pH 3, 6 and 9). At pH 4.6 there is the system destabilization due to the adsorption of the macromolecules with zero net charge. Under these conditions the greatest stability change was also observed (TSI from 8.38 to 23.97).

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