Antifertility Compound from the Seeds of Carica papaya

The antifertility effects of the isolated compound from the seeds of Carica papaya were investigated. The aim of this research is to obtain the chemical structure of antifertility compound againts spermatozoa of the white rat (Rattus novergicus) from the seeds of C. papaya. The ethyl acetate extract (7 g) was separated by solvent partition and a combination of column chromatography to yield a colorless solid isolated (26.1 mg). The chemical stucture of isolated compound was elucidated on the basis of spectroscopic evidences and identified as a 1,2,3,4-tetrahydropyridin-3-yl-octanoate. The isolated compound showed the significant difference of activity of compound compared with the control and decreased motility and viability and increased abnormality of the spermatozoa with 32%, 18% and 294%, respectively.