کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2401738 1102369 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5–MmpL5 efflux system
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5–MmpL5 efflux system
چکیده انگلیسی

SummaryTuberculosis (TB) remains the leading cause of mortality due to a bacterial pathogen, Mycobacterium tuberculosis. Moreover, the recent isolation of M. tuberculosis strains resistant to both first- and second-line antitubercular drugs (XDR–TB) threatens to make the treatment of this disease extremely difficult and becoming a threat to public health worldwide.Recently, it has been shown that azoles are potent inhibitors of mycobacterial cell growth and have antitubercular activity in mice, thus favoring the hypothesis that these drugs may constitute a novel strategy against tuberculosis disease.To investigate the mechanisms of resistance to azoles in mycobacteria, we isolated and characterized several spontaneous azoles resistant mutants from M. tuberculosis and Mycobacterium bovis BCG. All the analyzed resistant mutants exhibited both increased econazole efflux and increased transcription of mmpS5–mmpL5 genes, encoding a hypothetical efflux system belonging to the resistance–nodulation–division (RND) family of transporters. We found that the up-regulation of mmpS5–mmpL5 genes was linked to mutations either in the Rv0678 gene, hypothesized to be involved in the transcriptional regulation of this efflux system, or in its putative promoter/operator region.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 89, Issue 1, January 2009, Pages 84–90
نویسندگان
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