کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2401765 1102371 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antituberculosis activity of the molecular libraries screening center network library
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Antituberculosis activity of the molecular libraries screening center network library
چکیده انگلیسی

SummaryThere is an urgent need for the discovery and development of new antitubercular agents that target novel biochemical pathways and treat drug-resistant forms of the disease. One approach to addressing this need is through high-throughput screening of drug-like small molecule libraries against the whole bacterium in order to identify a variety of new, active scaffolds that will stimulate additional biological research and drug discovery. Through the Molecular Libraries Screening Center Network, the NIAID Tuberculosis Antimicrobial Acquisition and Coordinating Facility tested a 215,110-compound library against Mycobacterium tuberculosis strain H37Rv. A medicinal chemistry survey of the results from the screening campaign is reported herein.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 89, Issue 5, September 2009, Pages 354–363
نویسندگان
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