Multiple, independent, identical IS6110 insertions in Mycobacterium tuberculosis PPE genes

SummaryIS6110 is a transposable element found in Mycobacterium tuberculosis complex members. Regions of preferential IS6110 integration occur within the M. tuberculosis genome but the element has not previously been shown to exhibit any sequence-specific integration preferences. Here we provide evidence for multiple independent IS6110 insertions into identical, or near-identical, positions within the highly homologous 5′ region of 3 PPE genes.