کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2402136 1551713 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Potential correlates of BCG induced protection against tuberculosis detected in a mouse aerosol model using gene expression profiling
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Potential correlates of BCG induced protection against tuberculosis detected in a mouse aerosol model using gene expression profiling
چکیده انگلیسی

SummaryTuberculosis (TB) is responsible for more than 2 million deaths per year with the incidence of new cases rising throughout the world. Mycobacterium bovis bacillus Calmette Guerin (BCG) is currently the only available licensed vaccine against M. tuberculosis. Despite the variable protective efficacy in different populations it affords some protection, particularly against childhood and disseminated forms of the disease. BCG remains the gold standard for assessing other prospective TB vaccines, yet there is a lack of information on the mechanisms of BCG protection and consequently there are no definitive correlates of protection for this vaccine. In order to further studies in this area we assessed lung RNA homogenates from naïve, BCG vaccinated and aerosol challenged mice. We found increased IFN-γ levels in lungs of aerosol challenged mice previously vaccinated with BCG and a number of transcripts regulated by IFN-γ were also increased in the lungs of these animals. These transcripts represent a cluster of IFN-γ related transcripts that may assist in determining if BCG and maybe other potential vaccines will elicit protection against M. tuberculosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 86, Issues 3–4, May–July 2006, Pages 255–262
نویسندگان
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