کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2402145 1551713 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lipids of ‘Mycobacterium habana’, a synonym of Mycobacterium simiae with vaccine potential
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Lipids of ‘Mycobacterium habana’, a synonym of Mycobacterium simiae with vaccine potential
چکیده انگلیسی

Summary‘Mycobacterium habana’ was proposed as a distinct species within the genus Mycobacterium; however, it is actually a synonym of Mycobacterium simiae and included in the serotype I of this species. The potential use of ‘M. habana’ as a vaccine in both leprosy and tuberculosis has led to the analysis of its lipid composition in an attempt to define distinctive markers that could be used in the quality control of true strains of this bacterium. Lipids of taxonomic value (fatty and mycolic acids) are similar in ‘M. habana’ and M. simiae; nevertheless, they clearly differ on the basis of glycopeptidolipid (GPL) composition. Thus, contrary to M. simiae, most strains of ‘M. habana’ can be defined by the presence of three polar compounds, designated GPL-I, GPL-II and GPL-III, easily determined by thin-layer chromatography, and characterized, respectively, by the content of l-fucose, 2,4-di-O-Me-d-glucuronic acid, and 4-O-Me-d-glucuronic acid, as epitopes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Tuberculosis - Volume 86, Issues 3–4, May–July 2006, Pages 324–329
نویسندگان
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