کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2402484 | 1102795 | 2013 | 10 صفحه PDF | دانلود رایگان |
Diseases transmitted by arthropod vectors such as mosquitoes, ticks and sand flies greatly impact human and animal health and thus their control is important for the eradication of vector-borne diseases (VBD). Vaccination is an environmentally friendly alternative for vector control that allows control of several VBD by targeting their common vector. Recent results have suggested that subolesin/akirin (SUB/AKR) is good candidate antigens for the control of arthropod vector infestations. Here we describe the comparative effect of vaccination with SUB, AKR and Q38 and Q41 chimeras containing SUB/AKR conserved protective epitopes on tick, mosquitoes and sand flies vector mortality, molting, oviposition and/or fertility. We demonstrated that SUB vaccination had the highest efficacy (E) across all vector species (54–92%), Q41 vaccination had the highest vaccine E in mosquitoes (99%) by reducing female survival and fertility, and Q38 vaccination had the highest effect on reducing mosquito (28%) and sand fly (26%) oviposition. The effect of vaccination on different developmental processes in several important arthropod vectors encourages the development of SUB/AKR universal vaccines for the control of multiple vector infestations and reduction of VBD.
► Chimeras Q38 and Q41 containing tick subolesin (SUB) and mosquito akirin (AKR) protective epitopes were made.
► Vaccination with SUB, AKR and SUB/AKR chimeras controls tick, mosquito and sand fly infestations in mice.
► Vaccination with SUB had the highest efficacy across all vector species.
► Vaccination with Q41 had the highest efficacy in mosquitoes by reducing female survival and fertility.
► Vaccination with Q38 had the highest effect on reducing mosquito and sand fly oviposition.
Journal: Vaccine - Volume 31, Issue 8, 6 February 2013, Pages 1187–1196