کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2403402 | 1102904 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Impact of conjugate 7-valent vaccination in Belgium: Addressing methodological challenges Impact of conjugate 7-valent vaccination in Belgium: Addressing methodological challenges](/preview/png/2403402.png)
In Belgium, the 7-valent pneumococcal conjugate vaccine (PCV7) was introduced into the national schedule in 2007. The early impact of PCV7 vaccination on paediatric invasive disease was estimated by comparing pre- and post-vaccination incidence from national surveillance. In children <2 year-olds, vaccine-serotype incidence declined by 96% but non-vaccine-types increased 2–3-fold. Overall invasive disease decreased by 23–46%, depending on adjustment for under-reporting and pre-vaccine trends. Non-vaccine-types 1 and 19A had increased before PCV7 use, suggesting the contribution of other factors. Estimation of PCV7 impact comparing pre- and post-vaccination data should adjust for pre-vaccine trends, and serotype dynamics need further exploration.
Journal: Vaccine - Volume 29, Issue 16, 5 April 2011, Pages 2856–2864