Formulation and optimization of Embelin nanosuspensions using central composite design for dissolution enhancement

The purpose of the present investigation was to improve solubility and dissolution properties of poorly water soluble drug, Embelin, a herbal active ingredient by preparing nanosuspensions. The wet media milling technique was employed for the preparation of nanosuspensions. Further, nanosuspensions were freeze dried to generate nanocrystals. Rotatable central composite design was adopted to study the effects of independent variables viz. amount of stabilizer (Pluronic F68) and amount of milling agents (Zirconium beads) on dependent variables, particle size and % drug release at 30 min. Relationship between dependent and independent variables were further investigated by multiple linear regression analysis. A significant increase was found in the solubility and dissolution rate of the formulations. Differential scanning calorimetry and Powder X-ray diffraction studies confirmed decrease in drug crystallinity. Surface electron microscopy and Transmission electron microscopy revealed plate like morphology. Results suggested remarkable improvement in the dissolution properties of Embelin by preparing nanocrystals.

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