کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2483263 1556477 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Calcium alginate multi-unit oral dosage form for delayed release of celecoxib
ترجمه فارسی عنوان
فرم چند دارویی خوراکی آلژینات کلسیم برای انتشار تاخیری از سلکوکسیب
کلمات کلیدی
آلژینات سدیم، سلکوکسیب، دانه های پلیمری، آزادی روده ای
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی اکتشاف دارویی
چکیده انگلیسی

Calcium alginate beads containing celecoxib dissolved in a self-emulsifying phase were developed and characterized with the aim of ensuring a control on the site of drug release. The influence of different variables (concentration of the cross-linking agent, hardening time and amount of loaded drug) on the physico-chemical and biopharmaceutical properties was evaluated. Microscope images showed spherical dried beads and DSC revealed the absence of drug in crystalline state. The swelling behaviour of the beads was pH-sensitive and was not significantly influenced by the different variables selected. All the formulations were able to reduce the drug release at low pH and guaranteed a complete drug release at intestinal pH. In particular, at pH 7.4 the effect of the concentration of the cross-linking agent was evident: the rate and the extent of celecoxib release decreased significantly as the cross-linking agent concentration increased.According to the results presented in this study, adopting 15 min of hardening time in a solution of 100 mM CaCl2 and high drug loading, it is possible to obtain multi-unit systems characterized by good mechanical resistance, scarce swelling and release in acidic environment and good drug availability performances in the intestinal fluids.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Drug Delivery Science and Technology - Volume 26, April 2015, Pages 35–43
نویسندگان
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