کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2487378 | 1114413 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clavulanic Acid Decomposition Is Catalyzed by the Compound Itself and by Its Decomposition Products
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
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چکیده انگلیسی
The decomposition kinetics of the β-lactamase inhibitor clavulanic acid (CA) was investigated for CA concentrations between 2.5 and 20 gâLâ1, which is assumed to represent a characteristic range for an industrial CA production process. For each initial concentration, first order kinetics plots could be obtained, however the kinetic constant increased from 3.8âÃâ10â3 to 8.6âÃâ10â3 hâ1 with increasing initial CA concentration, indicating that CA accelerates its own decomposition by general acid-base catalysis. Furthermore, the kinetic constant remained approximately constant during the reaction, suggesting that also the decomposition products of CA had to show similar catalytic activity. This was confirmed experimentally by increased CA decomposition rates when CA degradation products were added to the reaction. A kinetic model is proposed, which is able to reliably predict the observed pseudo first order rate constants. The presented results should be considered in any process where highly concentrated CA solutions are employed, for example, during final downstream processing or in industrial fermentations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 8, August 2008, Pages 3451-3455
Journal: Journal of Pharmaceutical Sciences - Volume 97, Issue 8, August 2008, Pages 3451-3455
نویسندگان
Simone Brethauer, Martin Held, Sven Panke,