کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2500981 1557312 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preliminary characterization of dexamethasone-loaded cross-linked hyaluronic acid films for topical ocular therapy
ترجمه فارسی عنوان
خصوصیات اولیه از فیلم های اسید هیالورونیک اسید متصل به دگزامتازون برای درمان موضعی چشم
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی

The aim of this work was to design and characterize cross-linked hyaluronic acid (HA)–itaconic acid (IT) films loaded with dexamethasone sodium phosphate salt (DEX) for topical therapy of inflammatory ocular surface diseases. Films were chemically cross-linked with polyethylene glycol diglycidyl ether (PEGDE), then physical and mechanical characterization by stress–strain, X-ray diffraction, X-ray fluorescence spectrometry and swelling assays was conducted. A sequential in vitro therapeutic efficacy model was designed to assess changes in interleukin (IL)-6 production in an inflamed human corneal epithelial (HCE) cell line after film exposure. Changes in cell proliferation after film exposure were assessed using the alamarBlue® proliferation assay. Experimental findings showed desirable mechanical properties and in vitro efficacy to reduce cell inflammation. A moderately decreased proliferation rate was induced in HCE cells by DEX-loaded films, compared to commercial DEX eye drops. These results suggest that DEX and HA have opposite effects. The sequential in vitro therapeutic efficacy model arises as an efficient tool to study drug release from delivery systems by indirect measurement of a biological response.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 509, Issues 1–2, 25 July 2016, Pages 237–243
نویسندگان
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