کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2526169 1558010 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
H1-A, a compound isolated from Fusarium oxysporum inhibits hepatitis C virus (HCV) NS3 serine protease
ترجمه فارسی عنوان
H1-A، یک ترکیب جداشده از قارچ Fusarium oxysporum باعث پروتئاز سرین مهار ویروس هپاتیت سی (HCV) NS3 می شود
کلمات کلیدی
H1-A؛ ترکیب فعال زیستی؛ قارچ Fusarium oxysporum
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی طب مکمل و جایگزین
چکیده انگلیسی

The present study was aimed to isolate the active compounds from the fermentation products of Fusarium oxysporum, which had hepatitis C virus (HCV) NS3 protease inhibitory activity. A bioactive compound was isolated by reverse-phase silica-gel column chromatography, silica-gel column chromatography, semi-preparative reverse-phase High Performance Liquid Chromatography (HPLC), and then its molecular structure was elucidated based on the spectrosopic analysis. As a result, the compound (H1-A, 1) Ergosta-5, 8 (14), 22-trien-7-one, 3-hydroxy-,(3β, 22E) was isolated and identified. To the best of our knowledge, this was the first report on the isolation of H1-A from microorganisms with the inhibitory activity of NS3 protease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Journal of Natural Medicines - Volume 14, Issue 4, April 2016, Pages 299–302
نویسندگان
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