کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2538233 1559637 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lignans from the roots of Acorus tatarinowii Schott ameliorate β amyloid-induced toxicity in transgenic Caenorhabditis elegans
ترجمه فارسی عنوان
لیگنان ها از ریشه های Acorus tatarinowii Schott باعث بهبود سمیت ناشی از β آمیلوئید در Caenorhabditis elegans ترانس ژنیک می شود
کلمات کلیدی
Acorus tatarinowii؛ Lignan؛ C. elegans؛ فلج
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
چکیده انگلیسی

A novel tetralignan, tatarinan T (1) with the rare C8-C7′ linkage pattern, along with a known monolignan (2) were isolated from the roots of Acorus tatarinowii Schott. Their chemical structures were elucidated on the basis of NMR and X-ray diffraction analysis. We evaluated the protective effects of two rare lignans against β-amyloid toxicity by using CL4176 transgenic C. elegans model for the first time, and found that they significantly delayed paralysis of worms at the concentration of 100 μM. Compound 2 exhibited the more potential protective effect against β-amyloid toxicity, its value of PT50 extended up to 62.3% at 100 μM compared with control, especially, it still has 30.8% extension at 10 μM.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fitoterapia - Volume 108, January 2016, Pages 5–8
نویسندگان
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