کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2538233 | 1559637 | 2016 | 4 صفحه PDF | دانلود رایگان |
A novel tetralignan, tatarinan T (1) with the rare C8-C7′ linkage pattern, along with a known monolignan (2) were isolated from the roots of Acorus tatarinowii Schott. Their chemical structures were elucidated on the basis of NMR and X-ray diffraction analysis. We evaluated the protective effects of two rare lignans against β-amyloid toxicity by using CL4176 transgenic C. elegans model for the first time, and found that they significantly delayed paralysis of worms at the concentration of 100 μM. Compound 2 exhibited the more potential protective effect against β-amyloid toxicity, its value of PT50 extended up to 62.3% at 100 μM compared with control, especially, it still has 30.8% extension at 10 μM.
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Journal: Fitoterapia - Volume 108, January 2016, Pages 5–8