کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2539542 | 1122182 | 2009 | 4 صفحه PDF | دانلود رایگان |
A traditional preparation of Parmotrema saccatilobum (Taylor) Hale (Family: Parmeliaceae) is being considered for inclusion into the PNG national drug formulary by the Ministry of Health Taskforce on Traditional Medicines. The lichen preparation is traditionally used in the Milne Bay province of Papua New Guinea for analgesic and anti-inflammatory activities. A hexane extract of P. saccatilobum yielded the principle components atranorin and chloroatranorin. Atranorin and chloroatranorin were tested in a COX-1 and -2 enzyme inhibition assay, which showed that atranorin inhibited COX-1 in a dose dependent manner and suggests partial inhibition by atranorin and chloroatranorin of COX-2 and COX-1, respectively.
UV spectra of the COX-inhibitory components isolated from a Papua New Guinean analgesic and anti-inflammatory lichen preparation.Figure optionsDownload as PowerPoint slide
Journal: Fitoterapia - Volume 80, Issue 5, July 2009, Pages 270–273