کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2576392 1561353 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enhancement of 3-hydroxyanthranilic acid-induced T cell apoptosis through cinnabarinic acid generation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
Enhancement of 3-hydroxyanthranilic acid-induced T cell apoptosis through cinnabarinic acid generation
چکیده انگلیسی

.Induction of apoptosis by 100 μM of 3-hydroxyanthranilic acid (3HAA) was enhanced by SOD as well as MnCl2 and further promoted in the presence of catalase. Corresponding to apoptosis induction, the generation of cinnabarinic acid (CA) through the oxidation of 3HAA was enhanced by SOD or MnCl2 in the presence of catalase. Synthesized CA possessed more than 10 times higher apoptosis-inducing activity than 3HAA. CA generated from 3HAA possesses strong apoptosis-inducing activity in thymocytes through reactive oxygen species (ROS) generation, loss of mitochondrial membrane potential and caspase activation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Congress Series - Volume 1304, 1 November 2007, Pages 209–212
نویسندگان
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