کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
26286 43944 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel indotricarbocyanine dyes covalently bonded to polyethylene glycol for theranostics
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Novel indotricarbocyanine dyes covalently bonded to polyethylene glycol for theranostics
چکیده انگلیسی


• Water-soluble indotricarbocyanine dyes covalently bonded to polyethylene glycols are synthesized.
• Synthesized dyes show high photodynamic activity and tumor specificity.
• Phototherapeutic activity was observed on light exposure at a wavelengths of 668, 740 and 780 nm.
• The necrotic area after local photoirradiation was observed to a depth of 2.5 cm.

The synthesis methods for the indotricarbocyanine dyes covalently bonded to polyethylene glycols with varying degrees of polymerization have been developed. New indotricarbocyanine was synthesized in one step using the Mukayama reagent in polyethylene glycol with cesium fluoride as a basic catalyst. In vivo investigation of the phototherapeutic dye activity has shown selective recognition of malignant tissues, where accumulation of the dye was 4–5 times higher than in normal tissues. The necrotic area after local photoirradiation at the effective energy fluence 180 J/cm2, λ = 780 nm was observed to a depth of 2.5 cm making the synthesized dyes very promising for further pharmaceutic research.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Photochemistry and Photobiology A: Chemistry - Volume 316, 1 February 2016, Pages 31–36
نویسندگان
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