N-Acryloyl amino acid esters and peptides as radical acceptors in photoinduced decarboxylative radical reaction

• N-Acryloyl amino acid esters and peptides can be utilized as radical acceptors in the PET induced decarboxylation reaction.
• The photoreaction afforded modified amino acids and peptides under mild reaction conditions.
• This methodology can provide decarboxylated coupling peptides containing γ-amino acids.

The photoinduced electron transfer (PET) promoted decarboxylative radical additions of carboxylic acids using N-acryloyl amino acid esters and peptides as radical acceptors smoothly afforded the corresponding modified amino acids and peptides under mild reaction conditions. The radical additions of α-amino acids led to the formation of γ- and α-dipeptide, and peptides underwent peptide coupling via decarboxylation.

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