The T29C (rs1800470) polymorphism of the transforming growth factor-β1 (TGF-β1) gene is associated with restenosis after coronary stenting in Mexican patients

The aim of the present study was to establish the role of IL-6 and TGF-β1 gene polymorphisms in the risk of developing in-stent restenosis. Two IL-6 [rs1800796 (− 572 G > C), rs2069827 (− 1426 T > G)] and two TGF-β1 [rs1800469 (− 509 T > C), rs1800470 (T29C)] gene polymorphisms were analyzed by 5′ exonuclease TaqMan genotyping assays in a group of 244 patients, who underwent coronary artery stenting. Basal and procedure coronary angiography were analyzed, looking for angiographic predictors of restenosis and follow-up angiography was performed to screen for binary restenosis. Under the dominant and additive models adjusted for hypertension, stable angina, stent used, and diameter of stent, the TGF-β1 T29C (rs1800470) polymorphism was significantly associated with an increase risk of restenosis when compared to patients without restenosis (OR = 2.06, 95% CI: 1.03–4.11, PDom = 0.034 and OR = 1.64, 95% CI: 1.09–2.45, PAdd = 0.016). TGF-β1 polymorphisms were in linkage disequilibrium and one haplotype (TT) was significantly increased in patients with restenosis when compared to patients without restenosis (OR = 2.03, P = 0.041). In summary, our results suggest that the TGF-β1 T29C gene polymorphism could be involved in the risk of developing restenosis after coronary stent placement.