کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2796400 1155598 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical characteristics of people experiencing biochemical hypoglycaemia during an oral glucose tolerance test: Cross-sectional analyses from a UK multi-ethnic population
ترجمه فارسی عنوان
خصوصیات بالینی افراد مبتلا به هیپوگلیسمی بیوشیمیایی در طی آزمون تحمل گلوکز خوراکی: تجزیه و تحلیل مقطعی از جمعیت چند نژادی انگلستان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی

AimsPeople who experience biochemical hypoglycaemia during an oral glucose tolerance test (OGTT) may be insulin resistant, but this has not been investigated robustly, therefore we examined this in a population-based multi-ethnic UK study.MethodsCross-sectional data from 6478 diabetes-free participants (849 with fasting insulin data available) who had an OGTT in the ADDITION-Leicester screening study (2005–2009) were analysed. People with biochemical hypoglycaemia (2-h glucose <3.3 mmol/l) were compared with people with normal glucose tolerance (NGT) or impaired glucose regulation (IGR) using regression methods.Results359 participants (5.5%) had biochemical hypoglycaemia, 1079 (16.7%) IGR and 5040 (77.8%) NGT. Biochemical hypoglycaemia was associated with younger age (P < 0.01), white European ethnicity (P < 0.001), higher HDL cholesterol (P < 0.01), higher insulin sensitivity (P < 0.05), and lower body mass index (P < 0.001), blood pressure (P < 0.01), fasting glucose (P < 0.001), HbA1C (P < 0.01), and triglycerides (P < 0.01) compared with NGT and IGR separately in both unadjusted and adjusted (age, sex, ethnicity, body mass index, smoking status) models.ConclusionsBiochemical hypoglycaemia during an OGTT in the absence of diabetes or IGR was not associated with insulin resistance, but instead appeared to be associated with more favourable glycaemic risk profiles than IGR and NGT. Thus, clinicians may not need to intervene due to biochemical hypoglycaemia on a 2-h OGTT.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diabetes Research and Clinical Practice - Volume 104, Issue 3, June 2014, Pages 427–434
نویسندگان
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