کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2802940 1568958 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The association of macro- and micronutrient intake with growth hormone secretion
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
The association of macro- and micronutrient intake with growth hormone secretion
چکیده انگلیسی

ContextGrowth hormone (GH) is known to be nutritionally regulated, but the effect of dietary composition on detailed GH secretion parameters has not previously been comprehensively evaluated.ObjectiveThe objective of the study was to determine whether specific macro- and micronutrients are associated with discrete parameters of GH secretion among subjects with wide ranges of body mass index.DesignDetailed macro- and micronutrient intake was assessed by 4-day food records while GH secretion was assessed by standard stimulation testing in 108 men and women in one study (Study 1), and by overnight frequent blood sampling in 12 men in another study (Study 2).ResultsPeak stimulated GH was positively associated with vitamin C (r = + 0.29; P = 0.003), dietary fiber (r = + 0.27; P = 0.004), arachidic acid (r = + 0.25; P = 0.008), and behenic acid (r = + 0.30; P = 0.002) intake in univariate analysis. Controlling for age, gender, race/ethnicity, visceral fat, HOMA-IR, total caloric intake and these four dietary factors in step-wise multivariate modeling, peak GH remained significantly associated with vitamin C and visceral fat (both P < 0.05). In addition, vitamin C intake was associated with various parameters of endogenous GH secretion including basal GH secretion (r = + 0.95; P < 0.0001), GH half-life (r = + .75; P = 0.005), total GH production (r = + 0.76; P = 0.004), GH area-under-the-curve (r = + 0.89; P = 0.0001), mean log10 GH pulse area (r = + 0.67; P = 0.02), and overnight maximum (r = + 0.62; P = 0.03), nadir (r = + 0.97; P < 0.0001), and mean GH secretion (r = + 0.89; P = 0.0001).ConclusionsThese results suggest that certain micronutrients such as vitamin C intake are strongly and uniquely associated with stimulated and endogenous spontaneous GH secretion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Growth Hormone & IGF Research - Volume 22, Issues 3–4, June–August 2012, Pages 102–107
نویسندگان
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