کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2830513 1570715 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Major grass pollen allergens and components detected in a southern Chinese cohort of patients with allergic rhinitis and/or asthma
ترجمه فارسی عنوان
آلرژن ها و اجزای آلرژی گرما و عناصر عمده گرده علف گرایی در یک گروه خونی چینی در بیماران مبتلا به رینیت آلرژیک و / یا آسم
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی مولکولی
چکیده انگلیسی


• High rate of Bermuda grass sensitization in southern China was investigated, which was not reported before.
• This is the first study using component-resolved diagnosis on sensitization to grass pollen allergens in this region of China.
• Unlike Phl p 1 in Europe, Phl p 4 is the most common timothy component in southern China.
• Correlation between sensitization to the studied grass allergens and CCD suggested probable cross-reactivity.

There is so far a paucity of data about allergen component-resolved diagnosis, and the prevalence of grass pollen allergen components in China, in contrast to those from western countries. Even in this country, allergies to grass pollen allergen components in the vast south are inadequately described. This study aimed to determine the major sensitizing grass pollens in Guangzhou, the largest city in Guangdong province of southern China. Included in this study were 258 patients having allergic rhinitis with or without asthma and 88 healthy controls. ImmunoCap100 was used to examine the serum samples for sIgE to Bermuda, Timothy, and Humulus scandens. Subjects who tested positive were further examined for sIgE to Bermuda antigen Cyn d 1, Timothy antigens Phl p 1/4/5/6/7/11/12, and CCD. The relationship of grass pollen allergy to specific antigen sensitization was assessed. As a result, 22.5% of patients with allergic rhinitis and/or asthma were positive for Bermuda-sIgE, 13.6% for Timothy-sIgE, and 7.0% for Humulus scandens-sIgE. These patients were more likely to be sensitized compared with controls (P < 0.001). Of the Bermuda-sIgE positive patients, 53.4% were Cyn d 1 positive and 60.3% were Timothy-sIgE positive. Of the Timothy positive patients, 100% were positive for Phl p 4, 17.1% were positive for Phl p 1 and 8.6% tested positive for Phl p 5/6/7/11/12. Patients with high Bermuda-sIgE levels were more likely to be positive for other grasses. In 41.4% of Bermuda grass positive patients, CCD-sIgE was also positive. Sensitization to Phl p 4 was significantly correlated with CCD (rs = 0.928).In summary, we found that these southern Chinese patients with allergic rhinitis and/or asthma tested positive for Bermuda, Timothy, and Humulus scandens IgE. A high Bermuda-sIgE level may predict sensitization to other grasses. Correlations between sensitization to CCD and grass pollen allergens suggested a likelihood of cross-reactivity. Further in vitro inhibition assays are required to confirm this relationship.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 78, October 2016, Pages 105–112
نویسندگان
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