کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2846766 1571306 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evolution of lung breathing from a lungless primitive vertebrate
ترجمه فارسی عنوان
سیر تکاملی تنفس ریه از مهره دار اولیه بدون ریه
کلمات کلیدی
مارماهی؛ نفس كشيدن؛ CO2؛ سیر تکاملی؛ استقامت؛ سرفه کردن
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی فیزیولوژی
چکیده انگلیسی


• Lamprey “cough” is produced by a central rhythm generator sensitive to CO2.
• These data suggests that these elements critical for the evolution of breathing in tetrapods, were present in the most basal vertebrate ancestors prior to the evolution of the lung.
• We propose that the evolution of breathing in all vertebrates occurred through exaptations derived from these critical basal elements.

Air breathing was critical to the terrestrial radiation and evolution of tetrapods and arose in fish. The vertebrate lung originated from a progenitor structure present in primitive boney fish. The origin of the neural substrates, which are sensitive to metabolically produced CO2 and which rhythmically activate respiratory muscles to match lung ventilation to metabolic demand, is enigmatic. We have found that a distinct periodic centrally generated rhythm, described as “cough” and occurring in lamprey in vivo and in vitro, is modulated by central sensitivity to CO2. This suggests that elements critical for the evolution of breathing in tetrapods, were present in the most basal vertebrate ancestors prior to the evolution of the lung. We propose that the evolution of breathing in all vertebrates occurred through exaptations derived from these critical basal elements.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Respiratory Physiology & Neurobiology - Volume 224, April 2016, Pages 11–16
نویسندگان
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