کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2944453 1577106 2014 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Advances in the Understanding of Plaque Composition and Treatment Options : Year in Review
ترجمه فارسی عنوان
پیشرفت در درک ساختار پلاک و گزینه های درمان: سال در بازنگری
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی

Atherosclerosis research has classically followed 2 intertwining lines of investigation concerning atherosclerosis as a local process (the “high-risk plaque”) and as a systemic disease (the “high-risk patient”). Over time, the weight of attention has swung, like a pendulum, between these 2 related foci. With optimal medical therapy and attention to risk factors firmly established as fundamental aspects of management, in the past year, we have nevertheless perceived a shift in the pendulum toward renewed focus on the local plaque. We contend that this shift results from a convergence of major advances in understanding the biology of plaque progression, novel sophisticated invasive and noninvasive imaging modalities for the in vivo characterization of plaque composition and inflammation, and emerging data and technologies that have renewed interest in locally targeted interventions. Here, we review the dynamic and exciting progress that has occurred over the last 12 months in this arena, while acknowledging future work that remains to be done to refine and validate new imaging modalities and therapies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 63, Issue 16, 29 April 2014, Pages 1604–1616
نویسندگان
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