کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2947981 | 1577261 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Triad of Metabolic Syndrome, Chronic Kidney Disease, and Coronary Heart Disease With a Focus on Microalbuminuria
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کلمات کلیدی
TNFLOX-1Ox-LDLHDLNADPHAT1high-density lipoprotein - HDL یا لیپوپروتئین با دانسیته بالا یا چگالی بالاROS - ROSangiotensin II type 1 - آنژیوتانسین II نوع 1Angiotensin II - آنژیوتانسین دوcoronary heart disease - بیماری عروق کرونر قلبchronic kidney disease - بیماری مزمن کلیویAng II - دومMetabolic syndrome - سندرم متابولیکtumor necrosis factor - فاکتور نکروز تومورOxidized low-density lipoprotein - لیپوپروتئین با چگالی کم اکسید شدهLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)microalbuminuria - میکروآلبومینوریreduced nicotinamide adenine dinucleotide phosphate - کاهش نیکوتین آمید آدنین دینکلوتید فسفاتReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
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چکیده انگلیسی
Coronary heart disease remains a major cause of morbidity and mortality in the United States, and its incidence is rising worldwide. Because atherosclerosis is a chronic process, and it is often associated with certain lifestyle and risk factors such as hypertension, dyslipidemia, and insulin resistance, much emphasis is being placed on lifestyle modification and control of risk factors. It is being recognized that some lifestyle patterns such as overeating result in metabolic syndrome, which may play a role in the development of chronic kidney disease and coronary heart disease. Here, we focus on an important relationship between these 3 conditions, and we provide evidence that microalbuminuria develops in many patients with metabolic syndrome, may be an important correlate of chronic kidney disease and coronary heart disease, and may represent an important prognostic marker. Although the pathogenesis of microalbuminuria in metabolic syndrome is not clear, we suggest that microalbuminuria, chronic kidney disease, and coronary heart disease share common pathways involving inflammation and oxidative stress. We also discuss that a healthy lifestyle is essential for preventing and treating chronic kidney disease and coronary heart disease seen in patients with metabolic syndrome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the American College of Cardiology - Volume 57, Issue 23, 7 June 2011, Pages 2303-2308
Journal: Journal of the American College of Cardiology - Volume 57, Issue 23, 7 June 2011, Pages 2303-2308
نویسندگان
Freij MD, Abhishek MD, Sudhir MD, Jawahar L. MD, PhD,