کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
29517 1418077 2016 6 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
In vitro anticancer potential of BaCO3 nanoparticles synthesized via green route
ترجمه فارسی عنوان
پتانسیل ضدسرطانی آزمایشگاهی BaCO3 نانوذرات سنتز شده از طریق مسیر سبز
کلمات کلیدی
سنتز سبز؛ Mangifera indica؛ نانوذرات BaCO3؛ کاسپاز 3؛ سمیت سلولی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی


• Green synthesis is a simple, rapid, clean, inexpensive and eco-friendly.
• BaCO3 NPs were synthesized using an aqueous extract of Mangifera indica seed.
• Nanoparticles are characterized using FTIR, XRD, HR-TEM, EDX, SAED and XPS.
• BaCO3 NPs are potential for anticancer activity in vitro.

Green synthesis of nanoparticles is a growing research area because of their potential applications in nanomedicine. Barium carbonate nanoparticles (BaCO3 NPs) were synthesized using an aqueous extract of Mangifera indica seed as a reducing agent. These particles were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Transmission electron microscopy (TEM), selected area electron diffraction (SAED), Energy-dispersive-X-ray (EDX) and X-ray photoelectron spectroscopy (XPS) analysis. HR-TEM images are confirmed that green synthesized BaCO3 NPs have spherical, triangular and uneven shapes. EDX analysis confirmed the presence of Ba, C and O. The peaks at 2θ of 19.45, 23.90, 24.29, 27.72, 33.71, 34.08, 34.60, 41.98, 42.95, 44.18, 44.85, and 46.78 corresponding to (110), (111), (021), (002), (200), (112), (130), (221), (041), (202), (132) and (113) showed that BaCO3 NPs average size was ~ 18.3 nm. SAED pattern confirmed that BaCO3 NPs are crystalline nature. BaCO3 NPs significantly inhibited cervical carcinoma cells, as evidenced by cytotoxicity assay. Immunofluorescence and fluorescence assays showed that BaCO3 NPs increased the expression and activity of caspase-3, an autocatalytic enzyme that promotes apoptosis. According to the results, green synthesis route has great potential for easy, rapid, inexpensive, eco-friendly and efficient development of novel multifunctional nanoparticles for the treatment of cancer.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 156, March 2016, Pages 29–34
نویسندگان
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