کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3034439 | 1579517 | 2016 | 5 صفحه PDF | دانلود رایگان |
• Intrapericardia bradykinin and capsaicin induced different cardiac-somatic reflex.
• Intra-pericardia bradykinin induced a hypertension response while capsaicin induced a hypotension response.
• Bilateral vagotomy had no effects on the cardiac-somatic reflex induced by bradykinin but reduced the reflex induced by capsaicin.
• Vagotomy had no effects on the BP change induced by both bradykinin and capsaicin.
Patients with myocardial infarction experience various types of chest pain and autonomic disturbance symptoms. Studies in rats have shown that pericardial infusions of certain chemicals induce cardiac-related muscle pain and cardiovascular reflexes. In the present study, bradykinin or capsaicin was injected into the pericardial sac and the resulting cardiac-somatic reflexes and blood pressure (BP) alterations were record. We found that the cardiac-somatic reflex induced by bradykinin had a longer latency, shorter duration, and lower firing rate than that induced by capsaicin (p < 0.05). We also found that bradykinin induced a hypertensive response (p < 0.05), while capsaicin induced a hypotensive response (p < 0.05). Bilateral vagotomy had no effect on the cardiac-somatic reflex induced by bradykinin (p > 0.05) but reduced the reflex induced by capsaicin (p < 0.05). However, vagotomy had no effect on the BP alterations induced by both bradykinin and capsaicin (p > 0.05). These results suggest that bradykinin and capsaicin activate different pathways to induce cardiac-somatic and cardiovascular reflexes and that the vagus nerve is involved in TRPV1-related muscle pain modulation.
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Journal: Autonomic Neuroscience - Volume 198, July 2016, Pages 28–32