کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3036785 1184384 2015 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-aquaporin 4 antibody-positive acute disseminated encephalomyelitis
ترجمه فارسی عنوان
آنتیسفالومیلیت منتشر شده آنتی بادی مثبت حاد آنتی باکتری آپوپورین 4
کلمات کلیدی
ضد آنفلوآنزا 4، آنسفالومیلیت منتشر شده حاد، نوریت اپتیک، استروئیدها، واکسیناسیون
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی

ObjectiveTo describe the clinical and neuroimaging features of a young female patient with acute disseminated encephalomyelitis associated with anti-aquaporin-4 antibodies.MethodsThe patient had mild encephalopathy 14 days after influenza vaccination. Cerebrospinal fluid analysis revealed an increased cell count and a marked increase in myelin basic protein. Magnetic resonance imaging (MRI) demonstrated multiple lesions in the juxtacortical white matter. The patient was diagnosed with acute disseminated encephalomyelitis and treated with methylprednisolone pulse therapy. She recovered in 1 month. However, right retrobulbar optic neuritis appeared 2 months after discharge, and serum anti-aquaporin 4 antibodies were measured with a cell-based assay.ResultsAnti-aquaporin 4 antibodies were present in the patient’s serum. She was treated with a prolonged course of oral prednisolone. The patient was negative for serum anti-aquaporin 4 antibodies 8 months after the second clinical event, and prednisolone was discontinued 13 months after the second clinical event. Serum anti-aquaporin 4 antibodies remained negative 4 months after the discontinuation of prednisolone. There was no evidence of relapse at 9 months after discontinuation of steroids.ConclusionsThis case will expand the spectrum of anti-aquaporin-4 antibody-related central nervous system disorders. The measurement of anti-aquaporin 4 antibody may be considered in patients with a clinical diagnosis of acute disseminated encephalomyelitis and a second clinical event within a short interval.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Development - Volume 37, Issue 3, March 2015, Pages 339–343
نویسندگان
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