کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3064031 | 1580403 | 2014 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
IFI16 encodes a nucleic acid-sensor which detects latent EBV and triggers inflammasome activation. We analysed IFI16 variants in two multiple sclerosis (MS) case–control cohorts from Italy and Spain; results were combined with a previous study. A risk variant for celiac disease/rheumatoid arthritis, a polymorphic exon 7 duplication, and a copy number variant (CNV) in the 5′ region were genotyped. No significant association was detected, although heterogeneity was noted for the 5′ CNV in the Italian plus GeneMSA cohorts and the Spanish sample. Thus, IFI16 variants do not contribute to MS susceptibility, although some heterogeneity may exist for the 5′ CNV.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 271, Issues 1–2, 15 June 2014, Pages 49–52
Journal: Journal of Neuroimmunology - Volume 271, Issues 1–2, 15 June 2014, Pages 49–52
نویسندگان
Franca R. Guerini, Mario Clerici, Rachele Cagliani, Sunny Malhotra, Xavier Montalban, Diego Forni, Cristina Agliardi, Stefania Riva, Domenico Caputo, Daniela Galimberti, Rosanna Asselta, Chiara Fenoglio, Elio Scarpini, Giacomo P. Comi, Nereo Bresolin,